2005年

  1. Sasai, M., H. Oshiumi, M. Matsumoto, N. Inoue, F. Fujita, M. Nakanishi, and T. Seya. 2005. Cutting Edge: NF-kB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN Regulatory Factor 3 activation. J. Immunol. 174: 27-30.
  2. Nakao, Y., K. Funami, S. Kikkawa, M. Taniguchi, M. Nishiguchi, Y. Fukumori, T. Seya, and M. Matsumoto. 2005. Surface-expressed TLR 6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells. J. Immunol. 174: 1566-1573.
  3. Oshiumi, H., K. Shida, Y. Kimura, J. Katoh, S. Ohba, Y. Tamaki, T. Hattori, N. Yamada, N. Inoue, M. Matsumoto, S. Mizuno, and T. Seya. 2005. The regulator of complement activation (RCA) locus in the chicken: Identification of the chicken RCA gene cluster and functional characterization of the RCA proteins. J. Immunol. 175:1724-1734.
  4. Ishii, K., M. Kurita-Taniguchi, M. Aoki, T. Kimura, Y. Kashiwazaki, M. Matsumoto, and T. Seya. 2005. Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy. Immunol. Lett. 98: 280-290.
  5. Tsukada, H., A. Fukui, T. Tsujita, M. Matsumoto, T. Iida, and T. Seya. 2005. Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity. Int. J. Mol. Med. 15: 519-525.
  6. Uehori, J., K. Fukase, T. Akazawa, T. Uematsu, S. Akira, S. Funami, K. Shingai, M. Matsumoto, I. Azuma, K. Toyoshima, S. Kusumoto, and T. Seya. 2005. Dendritic cell maturation Induced by Muramyl Dipeptide (MDP) Derivatives: Monoacylated MDP confers TLR2/TLR4 activation. J. Immunol. 174: 7096-7103.
  7. Shingai, M., N. Inoue, M. Okabe, T. Akazawa, Y. Miyamoto, M. Ayata, K. Honda, M. Kurita-Taniguchi, M. Matsumoto, H. Ogura, T. Taniguchi, and T. Seya. 2005. Wild-type measles virus infection in human CD46/CD150-trangenic mice: CD11c-positive dendritic establish systemic viral infection. J. Immunol. 175: 3252-3261.
  8. Xie, X., H. He, M. Colonna, T. Seya, T. Takai, and B. D. Croy. 2005. Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol. Reprod. 73: 510-518.
  9. Wali, A, P. J. Morin, C. D. Hough, F. Lonard, T. Seya, M. Carbone, and H. I. Pass. 2005. Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). Lung Cancer. 48: 19-29.
  10. Okahira, S., F. Nishikawa, S. Nishikawa, T. Akazawa, T. Seya, and M. Matsumoto. 2005. Interferon-β induction through Toll-like receptor 3 depends on double-stranded RNA structure. DNA Cell Biol. 24: 614-623.
  11. Tsuji, Y., M. Hatanaka, T. Maeda, T. Seya, H. Takenaka, and A. Shimizu. 2005. Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines. Int J Mol Med. 16: 889-893.
  12. Seya, T., H. Oshiumi, M. Sasai, T. Akazawa, and M. Matsumoto. 2005. Molecules in Focus: TICAM-1 and TICAM-2: Toll-like receptor adapters that participate in induction of type 1 interferons. Int. J. Biochem. Cell Biol. 37: 524-529 (review).
  13. Seya T., M. Taniguchi, K. Funami, and M. Matsumoto. 2005. Antibodies against human Toll-like receptors (TLRs): TLR distribution and localization in human dendritic cells. J. Endotoxin Res. 11: 369-374 (review).

2004年

  1. Akazawa T., H. Masuda, Y. Saeki, M. Matsumoto, K. Takeda, S. Akira, I. Azuma, K. Toyoshima, and T. Seya. 2004. Adjuvant-mediated tumor regression and tumor- specific CTL induction are impaired in MyD88-deficient mice. Cancer Res. 64: 757-764.
  2. Begum, N. A., M. Kobayashi, Y. Moriwaki, M. Matsumoto, I. Azuma, K. Toyoshima, and T. Seya. 2004. Identification of differentially expressed novel genes from BCG-stimulated human macrophages by cDNA subtraction and mRNA-differential display. Infect. Immun. 72: 937-948.
  3. Ishida, H., M. Ayata, M. Shingai, I. Matsunaga, Y. Seto, Y. Katayama, N. Iritani, T. Seya, Y. Yanagi, O. Matsuoka, T. Yamano, and H. Ogura. 2004. Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus. Microbiol. Immunol. 48: 277-287.
  4. Funami, K., M. Matsumoto, H. Oshiumi, T. Akazawa, A. Yamamoto, and T. Seya. 2004. The cytoplasmic ‘linker region’ in Toll-like receptor 3 controls receptor localization and signaling. Int. Immunol. 16: 1143-54.
  5. Kimura, Y., N. Inoue, A. Fukui, H. Oshiumi, M. Matsumoto, M. Nonaka, S. Kuratani, T. Fujita, M. Nonaka, and T. Seya. 2004. A short consensus repeat -containing complement regulatory protein of Lamprey that participates in cleavage of lamprey Complement 3. J. Immunol. 173: 1118-28.
  6. Tsujita, T., H. Tsukada, M. Nakao, H. Oshiumi, M. Matsumoto, and T. Seya. 2004. Sensing Bacterial Flagellin by Membrane and Soluble Orthologs of Toll-like Receptor 5 in Rainbow Trout (Onchorhynchus mikiss). J. Biol. Chem . 279: 487588-487597.
  7. Matsumoto M., K. Funami K., H. Oshiumi, and T. Seya. 2004. Toll-like Receptor 3: A Link between Toll-like Receptor, Interferon and Viruses. Microbiol. Immunol. 48: 147-154. (review)
  8. Seya, T., M. Matsumoto, T. Akazawa, and K. Toyoshima. 2004. Differential maturation of dendritic cells by TLR adapters: application to immunotherapy. Cancer Immunotherapy Ed. By K. Toyoshima, J. C. Barrett, E. Klein, Y. Hashimoto, and H. Wakasugi. Princess Takamatsu Cancer Research Fund. Princess Takamatsu Symposia 34: 12-15.
  9. Matsuo-Tanabe, M., T. Kawamoto, S. Tanida, M. Matsumoto, and T. Seya. 2004. Toll-like receptor 2 agonists with unique properties synthesized with reference to a product of StreptosporangiumImmunology 2004 pp. 235-241.

2003年

  1. Hazeki, K., H. Masuda, K. Funami, N. Sukenobu, M. Matsumoto, S. Akira, O. Takeuchi, T. Seya and O. Hazeki. 2003. TLR-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and −independent pathways. Eur. J. Immunol. 33: 740-747.
  2. Inoue, N., M. Ikawa, T. Nakanishi, M. Matsumoto, M. Nomura, T. Seya, and M. Okabe. 2003. Disruption of the mouse CD46 caused an accelerated spontaneous acrosome reaction in sperm. Molec. Cell. Biol. 23: 2614-2622.
  3. Oshiumi, H., M. Matsumoto, K. Funami, and T. Seya. 2003. A novel adapter molecule that participates in Toll-like receptor-mediated interferon-beta induction. Nature Immunol. 4: 161-167.
  4. Oshiumi, H., T. Tsujita, K. Shida, M. Matsumoto, K. Ikeo, and T. Seya. 2003. Prediction of the prototype of the human Toll-like receptor gene family from the Pufferfish Fugu. rubripes genome. Immunogenetics 54: 791-800.
  5. Takeuchi, J., E. Watari, E. Shinya, Y. Norose, M. Matsumoto, T. Seya, M. Sugita, S. Kawana, and H. Takahashi. 2003. TGF-beta1 Maintains the Skin Homeostasis by Modulating Responsiveness of Langerhans cells Against Bacteria. Biochem. Biophys. Res. Commun. 306: 674-679.
  6. Uehori, J., S. Tsuji, M. Matsumoto, C. Kawata, T. Takeuchi, S. Akira, I. Azuma, K. Toyoshima, and T. Seya. 2003. Simultaneous blocking of human Toll-like receptor 2 and 4 suppresses myeloid dendritic cell maturation induced by Mycobacterium bovis bacillus Calmette-Gue´rin (BCG)-peptidoglycan (PGN). Infect. Immun. 71: 4238-4249.
  7. Shingai, M., M. Ayata, H. Ishida, I. Matsunaga, Y. Katayama, T. Seya, H. Tatsuo, Y. Yanagi, and H. Ogura. 2003. Receptor usage by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis. J. Gen. Virol. 84: 2133-2143.
  8. Matsumoto, M., K. Funami, M. Tanabe, H. Oshiumi, M. Shingai, Y. Seto, A. Yamamoto, and T. Seya. 2003. Subcellular localization of human Toll-like receptor 3 in human dendritic cells. J. Immunol. 171: 3154-3162.
  9. Oshiumi, H., K. Shida, M. Sasai, T. Fujita, M. Matsumoto, and T. Seya. 2003. Identification of the Toll-like receptor (TLR)-adapter that participates in TLR4-mediated interferon-beta induction. J. Biol. Chem. 278: 49751-49762.
  10. Tanabe, M., M. Kurita-Taniguchi, K. Takeuchi, K. Funami, M. Matsumoto, M. Shingai, M. Ayata, H. Ogura, and T. Seya. 2003. Up-regulation of a receptor for dsRNA, Toll-like receptor 3, in human myeloid dendritic cells via measles virus infection. Biochem. Biophys. Res. Commun.311: 39-48.
  11. Honda, K., S. Sakaguchi, C. Nakajima, A. Watanabe, H. Yanai, M. Matsumoto, T. Ohteki, T. Kaisho, A. Takaoka, S. Akira, T. Seya, and T. Taniguchi. 2003. Selective contribution of IFN-a/b signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectin. Proc. Natl. Acad. Sci. USA. 100: 10872-10877.
  12. Seya, T., T. Akazawa, M. Matsumoto, N. A. Begum, I. Azuma, and K. Toyoshima. 2003. Innate immune therapy for cancer: application of BCG-CWS and spirulina to patients with lung cancer. Anticancer Res. 23: 4369-4376. (review)

2002年

  1. Hirahashi, T., M. Matsumoto, K. Hazeki, Y. Saeki, M. Ui, and T. Seya. 2002. Activation of the human innate immune system by spirulina: Augmentation of interferon gamma production and NK cytotoxicity by oral administration of spirulina.Int. Immunopharmacology.2: 423-434.
  2. Kurita-Taniguchi, M., K. Hazeki, N. Murabayashi, A. Fukui, S. Tsuji, M. Matsumoto, K. Toyoshima, and T. Seya. 2002. Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF. Molec. Immunol.38: 689-700.
  3. Murakami H, H. Nagashima, Y. Takahagi, S. Miyagawa, T. Fujimura, K. Toyomura, R. Nakai, M. Yamada, T. Kurihara, T. Shigehisa, M. Okabe, T. Seya, R. Shirakura, and T. Kinoshita. 2002. Transgenic pigs expressing human decay?accelerating factor regulated by porcine MCP gene promoter.Mol. Reprod. Dev.61: 302-311.
  4. Masuda H., Y. Saeki, M. Nomura, T. Hirahashi, M. Matsumoto, M. Ui, L. L. Lanier, and T. Seya. 2002. High levels of RAE-1 isoforms on mouse tumor cell lines assessed by the anti-pan-Rae-1 polyclonal antibody confers tumor cell cytotoxicity on mouse NK cells.Biochem. Biophys. Res. Commun.290: 140-145.
  5. Matsumoto, M., S. Kikkawa, M. Kohase, K. Miyake, and T. Seya. 2002. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.Biochem. Biophys. Res. Commun.293: 1364-1369.
  6. Murabayashi, N., M. Kurita-Taniguchi, M. Ayata, H. Ogura, M. Matsumoto, and T. Seya. 2002. Susceptibility of human dendritic cells to measles virus depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.Microbes Infect.4: 785-794.
  7. Mori, Y., T. Seya, H. L. Huang, P. Akkapaiboon, P. Dhepakson, and K. Yamanishi. 2002. Human herpesvirus 6 variant A but not variant B induces fusion-from-without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46.J. Virol.76: 6750-6761.
  8. Nomura, M, M. Kurita-Taniguchi, K. Kondo, N.Inoue, M. Matsumoto, K. Yamanishi, M. Okabe, and T. Seya. 2002. Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: Identification of a CMV-responsive element in the CD46 promoter region.Eur. J. Immunol.32: 2954-2964.
  9. Begum, N. A., M. Kobayashi, Y. Moriwaki, M. Matsumoto, K. Toyoshima, and T. Seya. 2002. Mycobacterium bovis BCG cell wall and LPS induce a novel gene, BIGM103, whose main frame encodes a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures.Genomics80: 630-645.
  10. Hirano, A., M. Kurita-Taniguchi, Y. Katayama, M. Matsumoto, T. C. Wong, and T. Seya. 2002. Isoform-specific ligation of human CD46 enhances interferon gamma-dependent nitric oxide production in macrophages.J. Biochem (Tokyo).132: 83-91.
  11. Fukui, A., T. Yuasa, Y. Murakami, K. Funami, N. Kishi, T. Matsuda, T. Fujita, T. Seya, and S. Nagasawa. 2002. Mapping the sites responsible for factor I-cofactor for cleavage of C3b and C4b on human C4b-binding protein by deletion mutageneis.J. Biochem (Tokyo).132: 719-728.
  12. Kato, H., T. Inoue, N. Ishii Y. Murakami, M. Matsumura, T. Seya, and Pi-Chao Wang. 2002. A novel simple method to purify recombinant soluble complement receptor type 1 (sCR1) from CHO cell culture.Biotechnol. Bioprocess. Eng.7: 67-75.
  13. Diao, H., M. Kohanawa, Yimin, H. Nakajima, Y. Sato, T. Minagawa, and A. Nakane. 2002. Lipopolysaccharide triggers invasive streptococcal disease in mice through a tumour necrosis factor-alpha-dependent mechanism.Immunology.105: 344-349.

2001年

  1. Fukui, A., N, Inoue, M. Matsumoto, M. Nomura, Y, Matsuda, K. Toyoshima, and T. Seya. 2001. Molecular cloning and functional characterization of chicken Toll-like receptors.J. Biol. Chem.276: 47143-47149.
  2. Moriwaki, Y., N. A. Begum, M.. Kobayashi, S. Tsuji, M. Nomura, M. Matsumoto, K. Toyoshima, and T. Seya. 2001. Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF (PIG7), and estrogen-inducible gene, EET-1.J. Biol. Chem.276: 23065-23076.
  3. Tsuji, S., J. Uehori, M. Matsumoto, Y. Suzuki, A. Matsuhisa, K. Toyoshima, and T..Seya. 2002. Human intelectin is a novel soluble lectin that recognizes galactofranose in carbohydrate chains of bacterial cell wall.J. Biol. Chem.276: 23456-23463.
  4. Seya T. (one of the 96 authors). 2001. Functional annotation of a full-length mouse cDNA collection. The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium. Functional annotation meeting.Nature409: 685-690.
  5. Shiratori, I., S. Tsuji, M. Matsumoto, M. Nomura, K. Toyoshima, and T. Seya. 2001. Molecular cloning and functional characterization of guinea pig IL-12.Int. Immunol.13: 1129-1139.
  6. Shida K., H. Koizumi, M. Matsumoto, I. Shiratori, S. Kikkawa, S. Tsuji, N. A. Begum, K. Toyoshima, and T. Seya. 2001. High serum levels and additional species of IL-18 may participate in suppressing IgE levels in patients with atopic dermatitis.Immunol. Lett.79: 169-175.
  7. Matsumoto, M., T. Seya, S. Kikkawa, S. Tsuji, K. Shida, M. Nomura, M. Kurita-Taniguchi, H. Ohigashi, H. Yokouchi, H. Takami, A. Hayashi, I. Azuma, T. Masaoka, K. Kodama, and K. Toyoshima. 2001. IFNg-producing ability in blood of patients with lung cancer: production of IL-12 p40 and IL-18 in response to BCG-CWS.Int. Immunopharmacology1: 1559-1569.
  8. Shida, K., M. Matsumoto, S. Kikkawa, H. Okamura, S. Tsuji, Y. Fukumori, K. Toyoshima, and T. Seya. 2001. An alternative form of human IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies.J. Immunol.166: 6671-6679.
  9. Nishiguchi, M., M. Matsumoto, T. Takao, M. Hoshino, Y. Shimonishi, S. Tsuji, O. Takeuchi, S. Akira, K. Toyoshima, and T. Seya. 2001. Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions.J. Immunol.166: 2610-2616.
  10. Inoue, N., A. Fukui, M. Nomura, M. Matsumoto, K. Toyoshima, and T. Seya. 2001. A novel chicken membrane-associated complement-regulatory protein: Molecular cloning and functional characterization of a chicken membrane SCR protein.J. Immunol.166: 424-431.
  11. Kikkawa, S., M. Matsumoto, K. Shida, Y. Fukumori, K. Toyoshima, and T. Seya. 2001. Human macrophages produce dimeric forms of IL-18 which can be detected with monoclonal antibodies specific for inactive IL-18.Biochem. Biophys. Res. Commun.281: 461-467.
  12. Nomura, M., K. Matsumiya, M. Kitamura, A. Okuyama, M. Matsumoto, K. Toyoshima, and T. Seya. 2001. Gnomic analysis of ideopathic infertile patients with sperm-specific depletion of CD46.Exp. Clin. Immunogen.18: 42-50.
  13. Soldan S. S., A. Fogdell-Hahn, M. B. Brennan, B. B. Mittleman, L. Massacesi, T. Seya, and S. Jacobson. 2001. Elevated serum and CSF levels of soluble HHV-6 cellular receptor, membrane cofactor protein (MCP; CD46), in patients with multiple sclerosis.Ann. Neurol.50: 486-493.
  14. Koizumi, H., K. Sato-Matsumura, H. Nakamura, K. Shida, S. Kikkawa, M. Matsumoto, K. Toyoshima, and T. Seya. 2001. Distribution of IL-18 and IL-18 receptor in human skin: various forms of IL-18 are produced in keratinocytes.Arch. Dermatol. Res.293: 325-333.
  15. Yimin, M. Kohanawa, Y. Sato, and T. Minagawa. 2001. Role of T cells in granuloma formation induced by Rhodococcus aurantiacus is independent of their interferon-gamma production.J Med Microbiol.50: 688-694.

2000年

  1. Kurita-Taniguchi, M., A. Fukui, K. Hazeki, A. Hirano, S. Tsuji, M. Watanabe, M. Matsumoto, S. Ueda, and T. Seya. 2000. Activation of human macrophages through CD46 (measles virus receptor): Production of IL-12 p40 and nitric oxide in association with recruitment of SHP-1 to CD46.J. Immunol.165: 5143-5152.
  2. Tsuji, S., M. Matsumoto, O. Takeuchi, S. Akira, I. Azuma, A. Hayashi, K. Toyoshima, and T. Seya. 2000. Maturation of human human dendritic cells by cell-wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin: involvement of Toll-like receptors.Infect. Immun.68: 6883-6890.
  3. Kikkawa, S., M. Matsumoto, T. Sasaki, M. Nishiguchi, K. Tanaka, K. Toyoshima, and T. Seya. 2000. Complement activation on Mycoplasma fermentans induced mycoplasma clearance from infected cells: Probing the organism with mAbs against M161Ag.Infect. Immun.68: 1672-1680.
  4. Nomura, M., A. Tsujimura, N. A. Begum, M. Matsumoto, K. Toyoshima, and T. Seya. 2000. Mechanism of gene regulation of membrane cofactor protein (CD46) in mice: Identification and characterization of a silencer regulatory element in the 3′-flanking region of the murine CD46 gene.Biochem. J.351: 353-365.
  5. Shoji, T., I. Nakanishi, K. Kunitou, Y. Tsubakihara, Y. Hirooka, Y. Kishi, M. Hatanaka, M. Matsumoto, K. Toyoshima, and T. Seya. 2000. Determination of human urinary CD46 (membrane cofactor protein) with antibody-coated paramagnetic beads: Urine secretory CD46 levels are increased in patients with glomerular diseases.Clin. Immunol.95: 163-169.
  6. Kikkawa, S., K. Shida, M. Matsumoto, H. Okamura, S. Tsuji, M. Nomura, N. A. Begum, Y. Suzuki, K. Toyoshima, and T. Seya. 2000. A comparative analysis of the antigenic, structural and functional properties of three different preparations of recombinant human IL-18.J. Interferon Cytokine Res.20: 179-185.
  7. Begum N. A., Y. Murakami, S. Mikata, M. Matsumoto, H. Hatanaka, S. Nagasawa, T. Kinoshita, and T. Seya. 2000. Molecular remodeling of human CD46 for xenotransplantation: designing a potent complement regulator without measles virus receptor activity.Immunology100: 131-139.
  8. Saeki, Y., O. Hazeki, K. Hazeki, M. Ui, M. Matsumoto, K. Toyoshima, H. Akedo, and T. Seya. 2000. Participation of a MEK-independent pathway of MAP kinase activation in modulation of cell growth of mouse hepatoma cell lines.Int. J. Molec. Med.6: 155-160.
  9. Saeki, Y., K. Hazeki, H. Akedo., and T. Seya. 2000. Correlation between metastatic potency and the down-regulation of E-cadherin in the mouse hepatoma cell lines, G-1 and G-5.Oncol. Rep.7: 731-735.