{"id":224,"date":"2021-05-07T10:02:31","date_gmt":"2021-05-07T01:02:31","guid":{"rendered":"https:\/\/vaccine-immunology-nebuta.jp\/?page_id=224"},"modified":"2024-01-26T10:28:52","modified_gmt":"2024-01-26T01:28:52","slug":"expense","status":"publish","type":"page","link":"https:\/\/vaccine-immunology-nebuta.jp\/?page_id=224","title":{"rendered":"\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u8cbb\u3068\u7814\u7a76\u6982\u8981(\u304c\u3093)"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u702c\u8c37\u3000\u53f8<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u3010AMED \u4e8b\u696d\u3011<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">(1) 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class=\"wp-block-heading\">(6) \u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\u30fb\u7279\u5b9a\u9818\u57df\u7814\u7a76(\u304c\u3093)\u3001H14~H16<\/h5>\n\n\n\n<p><strong>\u300c\u81ea\u7136\u514d\u75ab\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u6297\u304c\u3093\u514d\u75ab\u7642\u6cd5\u300d<\/strong>\u3001 \u4ee3\u8868\u8005\u30016,900\u5343\u5186\u3001TLR2\u306eagonist MALP-404\u306e\u304c\u3093\u514d\u75ab\u7642\u6cd5\u3002\u30de\u30a4\u30b3\u30d7\u30e9\u30b9\u30de\u306e\u30ea\u30dd\u30bf\u30f3\u30d1\u30af(M161Ag, MALP-404)\u3092TLR2\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u540c\u5b9a\u3057\u3001\u305d\u306e\u304c\u3093\u514d\u75ab\u3078\u306e\u9069\u7528\u3092\u691c\u8a0e\u3057\u305f\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">(7) 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research\u3001\u304c\u3093\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u5bfe\u8c61\u3002\u4e3b\u306b\u304c\u3093\u306e\u30ef\u30af\u30c1\u30f3\u514d\u75ab\u7642\u6cd5\u306b\u304a\u3051\u308b\u514d\u75ab\u5897\u5f37\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306e\u7814\u7a76\u3068\u958b\u767a\u306b\u3064\u3044\u3066\u7a2e\u3005\u306eTLR2\u30ea\u30ac\u30f3\u30c9\u3001TLR3\u30ea\u30ac\u30f3\u30c9\u306e\u816b\u760d\u7d30\u80de\u30fb\u6a39\u72b6\u7d30\u80de\u5fdc\u7b54\u3092\u6bd4\u8f03\u3057\u3001TLR3\u30ea\u30ac\u30f3\u30c9(MyD88\u3092\u4f7f\u308f\u306a\u3044)\u306b\u30e1\u30ea\u30c3\u30c8\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">(8) 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class=\"wp-block-heading\">(9) \u6226\u7565\u7684\u5275\u9020\u7814\u7a76\u63a8\u9032\u4e8b\u696d(\u3055\u304d\u304c\u3051\u7814\u7a76)\u907a\u4f1d\u3068\u5909\u5316\u3001H6~H9<\/h5>\n\n\n\n<p><strong>\u300c\u60aa\u6027\u7d30\u80de\u3092\u9664\u53bb\u3059\u308b\u514d\u75ab\u6d3b\u6027\u5316\u907a\u4f1d\u60c5\u5831\u300d<\/strong>\u3001\u4ee3\u8868\u8005\u300140,000\u5343\u5186\u3001\u304c\u3093\u3092\u6392\u9664\u3059\u308b\u514d\u75ab\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u3068\u3057\u3066\u81ea\u7136\u514d\u75ab\u306b\u7740\u76ee\u3001ADCC, CDCC\u306e\u8d77\u52d5\u56e0\u5b50\u306e\u7814\u7a76\u3002\u5f53\u6642\u3001\u81ea\u7136\u514d\u75ab\u3068\u3044\u3046\u6982\u5ff5\u306f\u78ba\u7acb\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u304c\u3001\u305d\u306e\u5b58\u5728\u3092\u793a\u5506\u3057\u3001\u305d\u308c\u304c\u304c\u3093\u514d\u75ab\u306e\u6210\u7acb\u306b\u5927\u304d\u3044\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3092\u5b9f\u9a13\u7684\u306b\u793a\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u677e\u672c\u7f8e\u4f50\u5b50<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u3010AMED \u4e8b\u696d\u3011<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">(1) AMED\u5275\u85ac\u7dcf\u5408\u652f\u63f4\u4e8b\u696d\u3001H27~H28<\/h5>\n\n\n\n<p><strong>\u300c\u65b0\u898f\u304c\u3093\u514d\u75ab\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306e\u63a2\u7d22\u300d<\/strong>\u3001\u4ee3\u8868\u8005\u300130,412\u5343\u5186\u3001\u975e\u708e\u75c7\u6027\u306eTLR3\u7279\u7570\u30a2\u30b4\u30cb\u30b9\u30c8ARNAX\u3092\u958b\u767a\u3057\u305f\u3002\u30de\u30a6\u30b9\u79fb\u690d\u304c\u3093\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001ARNAX\u306f\u5168\u8eab\u6027\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u304c\u3093\u6297\u539f\u7279\u7570\u7684CTL\u3092\u8a98\u5c0e\u3057\u304c\u3093\u3092\u9000\u7e2e\u3055\u305b\u308b\u3053\u3068\u3001PD-L1\u6297\u4f53\u3068\u306e\u4f75\u7528\u3067\u816b\u760d\u9000\u7e2e\u52b9\u679c\u304c\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u3010\u305d\u308c\u4ee5\u5916\u306e\u7814\u7a76\u8cbb\u3011<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">(2) \u65b0\u5b66\u8853\u9818\u57df\u7814\u7a76(\u7814\u7a76\u8ab2\u984c\u63d0\u6848\u578b)\u3001H21~H23<\/h5>\n\n\n\n<p><strong>\u300c\u7d30\u80de\u5916\u6838\u9178\u306b\u3088\u308b\u514d\u75ab\u5fdc\u7b54\u60f9\u8d77\u306e\u5206\u5b50\u6a5f\u69cb\u300d<\/strong>\u3001\u4ee3\u8868\u8005\u300130,940\u5343\u5186\u3001\u5408\u6210dsRNA\u3067\u3042\u308bpoly(I:C)\u304c\u30af\u30e9\u30b9\u30ea\u30f3\u4f9d\u5b58\u7684\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3067\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u308b\u3053\u3068\u3001\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u306e\u30e9\u30d5\u30c8\u30ea\u30f3\u304c\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">(3) \u57fa\u76e4\u7814\u7a76 C\u3001H20~H22<\/h5>\n\n\n\n<p><strong>\u300c\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u5206\u5b50\u306b\u3088\u308b\u7d30\u80de\u5916\u6838\u9178\u8a8d\u8b58\u6a5f\u69cb\u300d<\/strong>\u3001\u4ee3\u8868\u8005\u30014,810\u5343\u5186\u3001\u7d30\u80de\u5916dsRNA\u306f\u7d30\u80de\u8868\u9762\u306e\u6838\u9178\u8a8d\u8b58\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u4ecb\u3057\u3066\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308cTLR3\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3001dsRNA\u306epoly(I:C)\u3068B\/C-type\u306eCpG\/GpC ODN\u306e\u53d6\u308a\u8fbc\u307f\u30ec\u30bb\u30d7\u30bf\u30fc\u304c\u5171\u901a\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">(4) \u57fa\u76e4\u7814\u7a76 C\u3001H15~H16<\/h5>\n\n\n\n<p><strong>\u300cToll-like receptor 3\u306b\u3088\u308b\u30a6\u30a4\u30eb\u30b9dsRNA\u8a8d\u8b58\u6a5f\u69cb\u306e\u89e3\u6790\u300d<\/strong>\u3001\u4ee3\u8868\u8005\u3001 4,550\u5343\u5186\u3001\u30d2\u30c8Toll-like receptor 3(TLR3)\u306b\u5bfe\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53(clone TLR3.7)\u3092\u4f5c\u88fd\u3057\u3001TLR3\u304c\u30d2\u30c8\u9aa8\u9ac4\u7cfb\u6a39\u72b6\u7d30\u80de\u306e\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306b\u5c40\u5728\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002TLR3\u306f\u7d30\u80de\u5185\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50TICAM-1\u3092\u4ecb\u3057\u3066IRF3,NF-kB,AP-1\u306e\u8ee2\u5199\u56e0\u5b50\u3092\u6d3b\u6027\u5316\u3057\u3001IFN-b\u7523\u751f\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u702c\u8c37\u3000\u53f8 \u3010AMED \u4e8b\u696d\u3011 (1) \u9769\u65b0\u7684\u304c\u3093\u533b\u7642\u5b9f\u7528\u5316\u7814 &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":111,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-left-sidebar.php","meta":{"footnotes":""},"class_list":["post-224","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/pages\/224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=224"}],"version-history":[{"count":13,"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/pages\/224\/revisions"}],"predecessor-version":[{"id":402,"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/pages\/224\/revisions\/402"}],"up":[{"embeddable":true,"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=\/wp\/v2\/pages\/111"}],"wp:attachment":[{"href":"https:\/\/vaccine-immunology-nebuta.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}